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Nolvadex Citrate binds to estrogen receptors thus blocking the hormones action on target tissues and achieving an anti-estrogenic effect. Also worth noting is the fact that Nolvadex is an estrogen agonist in the liver and is capable of mimicking estrogen in this organ. At first glance you may wonder why this could be considered a good thing, however, when you realize that estrogen positively effects HDL (good) cholesterol values in the liver its value in this instance becomes obvious. As you know, steroid use tends to suppress HDL levels and raise LDL levels significantly leading to increased cholesterol levels and cardiac risk. Adding Nolvadex may therefore form a protective function in this case, although it certainly does not save the liver from all the other hazards involved with the use of c-17 alpha alkylated orals. Nolvadex Citrate is a selective estrogen receptor modulator. 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