Volume of distribution of chloroquine

Discussion in 'Northwest Pharmacy Canada' started by cjslade, 03-Mar-2020.

  1. Veronika ) XenForo Moderator

    Volume of distribution of chloroquine


    Conceptual illustration of effect of drug distribution into tissue space on V: Consider 100 mg of a drug is added to 1 L of water in a beaker under two circumstances and the liquid is sampled for drug concentration (C). , also known as apparent volume of distribution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.) is possible, and would indicate that the drug is highly distributed into tissue.

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    Plasma volumes of distribution up to 65,000 L for chloroquine and 44,257 L for hydroxychloroquine have been reported 71, 75, 77. Normalized by body mass, reported volumes of distribution for chloroquine have ranged from 204 to 800 L/kg depending on the sensitivity of the method of detecting chloroquine. If the volume is between 7 4 and 15 7 L, the drug is thought to be distributed throughout the blood plasma and red blood cells. If the volume of distribution is larger than 42, the drug is thought to be distributed to all tissues in the body, especially the fatty tissue. Results following a single dose of a 200 mg tablet versus i.v. infusion 155 mg, demonstrated a half-life of about 40 days and a large volume of distribution. Peak blood concentrations of.

    Volume of distribution may be increased by kidney failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula. In rough terms, drugs with a high lipid solubility (non-polar drugs), low rates of ionization, or low plasma protein binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma protein binding in the body's environment.

    Volume of distribution of chloroquine

    How medicines are made pharmacokinetics through the lens of., Understanding Volume of Distribution – Certara

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  6. For example, if 1000 mg of a drug is given and the subsequent plasma concentration is 10 mg/L, that 1000 mg seems to be distributed in 100 L dose/volume = concentration; 1000 mg/ x L = 10 mg/L; therefore, x= 1000 mg/10 mg/L = 100 L.

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    The drug has an apparent volume of distribution of 116-285 L/kg in healthy adults. Animal studies indicate that concn of chloroquine in liver, spleen, kidney, and lung are at least 200-700 times higher than those in plasma, and concentration of the drug in brain and spinal cord are at least 10-30 times higher than those in plasma. Although the high volume of distribution tells us that chloroquine distributes into compartments other than 1. - 4, and the concentration in those compartments is probably higher than the concentrations in blood, the GG data do not tell us how low the concentration in blood can be to yield a concentration of 32 microg/ml in Bb cyst infected tissue. In our studies, a total of 431 plasma samples were prepared from 22 healthy subjects and 69 patients with vivax malaria for three different studies studies Ia, Ib, and II. In study Ia, a single dose of HCQ sulfate of 400 mg 310 mg as HCQ was administered to six healthy South Korean male volunteers and serial.

     
  7. Cicaripgeargo Well-Known Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine Oral Uses, Side Effects, Interactions. Plaquenil Oral Uses, Side Effects, Interactions. Plaquenil hydroxychloroquine sulfate dose, indications.
     
  8. hommes User

    Plaquenil and vision" Lupus Community - Support Group Plaquenil can cause retinal damage which can be reversed if caught early. The damage to your eye would start with your peripheral vision which is why a thorough opthamalic exam and visual field.

    Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at.
     
  9. yearzero Well-Known Member

    Drug spotlight on hydroxychloroquine Lupus Foundation of. Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Using this formula, the dosage for a 150-pound person would be 443 mg/day, as one kilogram equals 2.2 pounds. Because HCQ is formulated as a 200 mg tablet, many people taking it for lupus will take two pills per day.

    RheumNow Hydroxychloroquine Blood Levels in SLE MedPage.