Chloroquine eye exam for macular lesions

Discussion in 'North West Pharmacy Canada' started by rotveller, 06-Mar-2020.

  1. pastor08 XenForo Moderator

    Chloroquine eye exam for macular lesions


    Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating.

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    Abnormal test is the visual field test, you may be asked to repeat it to make sure of the results. You will be told if any other tests are necessary and when you should be screened again. In cases of possible retinopathy, you will be recommended to continue taking 8 9 Macular Society Eye screening for patients taking hydroxychloroquine She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to presentation. Fundus examination shows a subtle bull’s-eye macular lesion characterized by a central island of pigment surrounded by a depigmented zone of RPE atrophy, which itself is encircled by a hyperpigmented ring. The lesion may be more obvious on autofluorescence than on ophthalmoscopy. This stage can be missed before cataract surgery.

    Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area).

    Chloroquine eye exam for macular lesions

    Plaquenil Screening - Retinal Diagnostic Center, Hydroxychloroquine Plaquenil Toxicity and Recommendations.

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  6. Applies to chloroquine compounding powder, injectable solution, oral tablet. Ocular. Maculopathy and macular degeneration may be irreversible. Irreversible retinal damage has been reported in patients receiving long-term or high-dose 4-aminoquinoline therapy. Retinopathy has been reported as dose related.

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    Retinal lesions associated with chloroquine, although more rarely encountered, have proved to be irreversible. 20/200 in the right eye and 20/50 in the left eye. External examination of the eyes and intraocular pressures were within normal limits. Biomicro-. The occurrence of macular lesions in pa. We herein report the optical coherence tomography OCT findings in a case of chloroquine-induced macular toxicity, which to our knowledge, has so far not been reported. A 53- year-old lady on chloroquine for treatment of rheumatoid arthritis developed decrease in vision 36 months after initiation of the treatment. A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to.

     
  7. el_pro XenForo Moderator

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Chapter 57. Rheumatoid Arthritis, Self-Assessment Questions Chronic ulcerative stomatitis Diagnostic and management. Pharmacotherapy of Sickle Cell Disease
     
  8. seoseoman Moderator

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Hydroxychloroquine-Induced Retinal Toxicity - American Academy of. Hydroxychloroquine I take Hydroxychloroquine 20. - LUPUS UK Hydroxychloroquine Oral Route Precautions - Mayo Clinic
     
  9. Mad_Max Well-Known Member

    Lupus and Sun Exposure If you have lupus, protecting yourself from sun exposure is an essential part of managing your condition. Many people with lupus experience photosensitivity or unusual sensitivity to sunlight. This can trigger symptoms such as skin rashes, itching, and burning.

    Hydroxychloroquine Sulfate Sunburn Reports - DrugInformer
     
  10. funduk07 Moderator

    Common Medications That May Be Toxic to the Retina Retinopathy is a well-characterized side effect of treatment and includes cotton-wool spots, intraretinal and pre-retinal hemorrhage, and macular edema See Figure 3. A wide incidence range of 18 percent to 86 percent has been reported for interferon retinopathy. 24 Signs develop within two weeks to three months of treatment onset; patients may complain of blurred vision or be entirely.

    Plaquenil Oral Interactions with Other Medication