Chloroquine method of action lysosome

Discussion in 'Hydroxychloroquine Sulfate' started by andrey2505, 13-Mar-2020.

  1. Sergey Nazarov New Member

    Chloroquine method of action lysosome


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    Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion of the drug acting as a channel or as a carrier and which is the protonation state of its chloroquine substrate is the subject of a. The mechanisms of action of hydroxychloroquine and chloroquine remain under continuous study in modern molecular medicine 17,18 using advanced tools in computational biology 19, synthetic biology. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy.

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    Chloroquine method of action lysosome

    The lysosomal inhibitor, chloroquine, increases cell surface., Mechanisms of action of hydroxychloroquine and chloroquine.

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  6. Although the precise mechanism underlying the antimalarial effects of chloroquine remains unknown, chloroquine seems to exert its effects through the weak-base lysosome-tropic feature. When chloroquine enters the lysosome, it becomes protonated because of the low pH within the lysosome, and accumulation of the protonated form of chloroquine within the lysosome leads to less acidic conditions and, thereby, decreased lysosomal function.

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    Several lysosomal inhibitors such as bafilomycin A1 BafA1, protease inhibitors and chloroquine CQ, have been used interchangeably to block autophagy in in vitro experiments assuming that they all primarily block lysosomal degradation. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Hydroxychloroquine is preferred due to its safer profile. Mar 08, 2011 Chloroquine-treated ARPE-19 cells demonstrate a marked increase in vacuolation and dense intracellular debris. These are identified as chloroquine-dilated lysosomes and lipid bodies with LAMP-2 and LipidTOX co-localization, respectively. Dilation is an indicator of lysosomal dysfunction.

     
  7. formal Moderator

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Hydroxychloroquine Plaquenil Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Can Rheumatoid Arthritis Patients Get a Flu Shot? 15 Facts on.
     
  8. mxteam User

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Hydroxychloroquine - Wikipedia Plaquenil User Reviews for Systemic Lupus. - Taking Plaquenil for Rheumatoid Arthritis
     
  9. unregistered Moderator

    Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Aug 14, 2017 Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis Retinal Damage. Neurological Disorders. Blood Disorders. Hearing Disorders. Other Side Effects.

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  10. ownb Moderator

    Aralen, Chloroquine phosphate chloroquine dosing. Non-chloroquine-resistant 1 g 600 mg base PO, THEN. 500 mg 300 mg base PO 6-8 hours later, THEN. 500 mg 300 mg base PO at 24 hours & 48 hours after initial dose.

    Chloroquine - Uses, Dosage, Side Effects, Composition & more.