She said the muscles were a touch irritated as well. Diagnosed small fiber p neuropathy due to autoimmune issues and recommended I get a second opinion from a different rheumatologist and for treatment of the neuropathy. Puckering of tongue plaquenil Chloroquine peremption Hydroxychloroquine hemodialysis Diagnosed small fiber p neuropathy due to autoimmune issues and recommended I get a second opinion from a different rheumatologist and for treatment of the neuropathy. Usually she said small fiber neuropathy is reversible, with good aggressive treatment. Small fiber neuropathy frequently is associated with neuropathic pain. The clinical history and physical examination often are sufficient to make the diagnosis of a small fiber neuropathy; however, additional functional and pathological tests may help to confirm the diagnosis. And small-fiber neuropathy. Heterozygous mutations in TRPA1, which encodes the transient receptor potential cation channel, can cause familial episodic pain syndromes, and variants of genes coding for the voltage-gated sodium channels Nav1.8 SCN10A and Nav1.9 SCN11A lead to small-fiber neuropathy and congenital insensitivity to pain, I know this is true as it reversed itself last time, though it was not this bad. Thanks for the information, Tammy15 mg prednisone150 mg Imuran.5 mg clonazepam Hi Tammy, This is what Wikipedia says about treatment of Small Fiber Neuropathy: Treatment is based on the underlying cause, if any. Usually she said small fiber neuropathy is reversible, with good aggressive treatment. Can plaquenil help with small fiber neuropathy Use of Intravenous Immunoglobulin in Small Fiber Neuropathy., Diagnosis and Treatment of Pain in Small Fiber Neuropathy Hydroxychloroquine diagnostic testsCan plaquenil cause eye painHydroxychloroquine renal dosingPlaquenil and genetic markerPlaquenil and tick bites Some autonomic symptoms of small fiber neuropathy include. Dryness of mouth, dry eyes and dry mucus membranes. Postural hypotension or dropping of blood pressure with postural changes. Dizziness, particularly with change of position, Difficulty in temperature regulation, feeling too hot or too cold. Small Fiber NeuropathyCausesSymptomsTreatmentDiagnosis. Small Fiber Neuropathy More than just burning feet and.. Peripheral Neuropathy and Sjogren's. Background Systemic lupus erythematosus SLE is an inflammatory, autoimmune, multiorgan disease often involving the central and peripheral nervous systems. Objective To determine whether there is a selective small-diameter nerve fiber neuropathy in patients with SLE. Design. Treatment for Autoimmune Small-fiber Neuropathy. SYNOPSIS The cause of most cases of small-fiber neuropathy is uncertain, but many patients have accompanying autoimmune biomarkers. In a carefully selected group of such patients, intravenous immunoglobulin treatment appears to provide benefit. SOURCE Liu X, Treister R, Lang M, Oaklander AL. Special diagnostic tests, including the technique of superficial, punch skin biopsies small biopsies of 3 millimeters and not requiring any stitches, can help in the diagnosis. A relatively rare neuropathy can cause significant weakness in Sjogren's patients.