Bulleye chloroquin retinopathy

Discussion in 'Health Canada Drug Database' started by Turistka, 29-Feb-2020.

  1. assesor Guest

    Bulleye chloroquin retinopathy


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Chloroquine is a potent drug used for the treatment of various diseases, including malaria and a range of connective tissue disorders. Chloroquine retinopathy is an important complication that may appear even years after cessation of the drug, presenting with impaired visual acuity, central vision loss and progressive damage that could result in irreversible blindness. Hydroxychloroquine or chloroquine ingestion can cause atrophy of the retinal pigment epithelium in the form of a bull’s eye maculopathy in cases of chronic use. Early detection of toxicity prior to the development of the bull’s eye is important, as loss of visual acuity is usually irreversible at that stage. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Bulleye chloroquin retinopathy

    Retinal Physician - Hydroxychloroquine Maculopathy An Update., Macular Telangiectasia A cause of bull’s eye maculopathy

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  7. Jul 30, 2019 Before the administration of chloroquine, the patient had only a mild skin erythema in the irradiated area, which was consistent with the radiotherapy dose she had received. On day 3 of chloroquine therapy, she developed localized brisk bullous eruptions in the irradiated area, which developed into a patch of fulminant moist desquamation.

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    Bull's-eye maculopathy has been associated with various macular diseases, most notably chloroquine and hydroxychloroquine maculopathy, cone dystrophy, and Stargardt disease Table 1. To our knowledge, bull's-eye maculopathy associated with chronic macular holes has not been previously reported. Bull's-Eye Maculopathy. and Rita Dinis Gama, M. D. A 64-year-old woman with systemic lupus erythematosus and normal renal function had received chloroquine at a dose of 3.24 mg per kilogram of lean body weight per day for 6 years cumulative dose, 390 g. Retinal photograph showing classic “bull’s eye” retinopathy of hydroxychloroquine toxicity, which represents atrophy of the retinal pigment epithelium. This is a relatively late change, and good screening can detect toxicity before any bull’s eye is visible.

     
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    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. CST - Chloroquine Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika. Chloroquine for research Cell-culture tested InvivoGen
     
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