Metoprolol in pregnancy

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    Metoprolol in pregnancy


    Metoprolol is used for a number of conditions, including hypertension, angina, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, congestive heart failure, and prevention of migraine headaches. receptors in the heart, metoprolol is also prescribed for off-label use in performance anxiety, social anxiety disorder, and other anxiety disorders. Metoprolol is sold in formulations that can be taken by mouth or given intravenously. Side effects, especially with higher doses, include dizziness, drowsiness, fatigue, diarrhea, unusual dreams, trouble sleeping, depression, and vision problems. Metoprolol may also reduce blood flow to the hands or feet, causing them to feel numb and cold; smoking may worsen this effect. Due to the high penetration across the blood-brain barrier, lipophilic beta blockers such as propranolol and metoprolol are more likely than other less lipophilic beta blockers to cause sleep disturbances such as insomnia and vivid dreams and nightmares. Serious side effects that are advised to be reported immediately include symptoms of bradycardia (resting heart rate slower than 60 beats per minute), persistent symptoms of dizziness, fainting and unusual fatigue, bluish discoloration of the fingers and toes, numbness/tingling/swelling of the hands or feet, sexual dysfunction, erectile dysfunction, hair loss, mental/mood changes, depression, breathing difficulty, cough, dyslipidemia and increased thirst. The FDA categorizes metoprolol as a category C medication, which means it should only be given during pregnancy when the potential benefit outweighs the potential risk. Category C medications are those that have had harmful effects on the fetus during animal studies and have not been adequately studied in human subjects. Yes, but only after the patient’s healthcare provider has weighed up the pros and cons of such an action and taken several factors into account. For example, they will need to decide if the health risks the medication presents are greater than the health risks associated with non-treatment of the patient’s condition. If a healthcare provider does decide to administer metoprolol to a pregnant woman, he or she should closely observe the patient and fetus for the duration of the gestation period. Once the baby is born, he or she should be closely monitored for signs and symptoms of beta-blockade in the 48 hours after birth. Side Effects in Pregnant Patients Although there has been little controlled human research on the effects of metoprolol and other beta blockers during pregnancy, there have been some individual, anecdotal reports on the effects of some of these other beta blockers.

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    Metoprolol serum levels in 3- to 5-day-old breastfed infants ranged from 0.5 to 2.9 mcg/L after maternal doses of 50 or 100 mg twice daily.39 A woman was taking metoprolol 100 mg daily for hypertension during pregnancy and postpartum. The plasma drug concentration-effect relationship after an oral dose of 100 mg metoprolol has been studied in 8 women in the third trimester of a pregnancy. Pregnancy Category C. Upon confirming the diagnosis of pregnancy, women should immediately inform the doctor. Metoprolol has been shown to increase postimplantation loss and decrease neonatal survival in rats at doses up to 11 times the maximum daily human dose of 450 mg, when based on surface area.

    Ischemic Heart Disease: Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred. When discontinuing chronically administered metoprolol, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of 1 to 2 weeks and the patient should be carefully monitored. If angina markedly worsens or acute coronary insufficiency develops, metoprolol administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Patients should be warned against interruption or discontinuation of therapy without the physician’s advice. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue metoprolol therapy abruptly even in patients treated only for hypertension. Metoprolol tartrate, USP is a selective beta1-adrenoreceptor blocking agent, available as 25, 50 and 100 mg tablets for oral administration. Metoprolol tartrate is (±)-1-(isopropylamino)-3-[p-(2-methoxyethyl) phenoxy]-2-propanol (2:1) dextro-tartrate salt, and its structural formula is: Metoprolol tartare, USP is a white, practically odorless, crystalline powder with a molecular weight of 684.82. Use of beta-blockers during pregnancy may affect the growing fetus by slowing its heart rate, and lowering its blood sugar level and blood pressure. Beta-blockers can also pass to the infant through breast milk, causing low blood pressure, difficulty breathing and a slowed heart rate. Women should inform their doctor if they are trying to get pregnant or become pregnant while on beta-blockers or are breastfeeding. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the Web MD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.

    Metoprolol in pregnancy

    Metoprolol succinate - FDA, Plasma concentration — effect relationship of metoprolol during and.

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  5. Metoprolol -- Teratogenic Agent There is evidence to indicate that exposure to Metoprolol during pregnancy may have a teratogenic effect on the fetus. A teratogen is a substance that can cause birth defects.

    • Metoprolol -- Teratogenic Agent Symptoms, Diagnosis..
    • METOPROLOL TARTRATE - DailyMed.
    • Anyone used Toprol metoprolol throughout pregnancy..

    As labetalol 5 to 20 mg, metoprolol 1 to 5 mg, hydralazine 5 to 10 mg, or nicardipine 0.2-mg increments may be titrated to decrease systolic BP to target values. Since metoprolol and labetalol have beta-blocking Well I take metoprolol for a different heart condition, but I absolutely cannot go without taking anything. For my first pregnancy my OB switched me to labetolol, and for my second pregnancy they said it was ok for me to take my metoprolol. May 14, 2012. The FDA categorizes metoprolol as a category C medication, which means it should only be given during pregnancy when the potential benefit.

     
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