Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Plaquenil dosage by weight Plaquenil spotting Plaquenil and 5hr energy interactions Hydroxychloroquine plaquenil drug class Systemic sclerosis scleroderma is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 10+ years, also take medication Lasix, and have Osteoporosis Hi Vanessa, My son was put on Plaquenil 9 months after being diagnosised with sine scleroderma. At the time, he had esophageal dysmotility 2/3rds of his esophagus, positive ANA, + Anti-RNA Polymerase 1/111, severe fatigue, and tightening of the chest cavity chondro. Nonsterodial anti-inflammatory drugs and hydroxychloroquine Plaquenil help both conditions. Most patients with pure schleroderma do not benefit from corticosteroids. Methotrexate, azathioprine, prednisone or cyclophosphamide help lupus and overlap syndromes, and perhaps scleroderma lung disease. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Scleroderma plaquenil Why Are Scleroderma Patients so Stubborn? - Scleroderma News, Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums Chloroquine gametocidalDoes plaquenil cause eye painLysotracker chloroquineTeva chloroquine and alcoholPlaquenil generico en mexico Because no two cases of Scleroderma are alike, identifying your disease subtype, stage, and involved organs is very important in determining the best course of action for treatment. Current therapies use medications that focus on the four main features of the disease inflammation, autoimmunity, vascular disease, and tissue fibrosis. Scleroderma Treatment Options Johns Hopkins Scleroderma Center. Lupus and Scleroderma Overview - Lupus International. Scleroderma Skin Involvement Itching Pruritus. I had a biopsy and my doctor said he believes it is morphea. I am waiting on my blood test to come back and he said as soon as it does he will put me on both methotrexate and doctor is a very good derm. May 18, 2019 Diagnosis. Because scleroderma can take so many forms and affect so many different areas of the body, it can be difficult to diagnose. After a thorough physical exam, your doctor may suggest blood tests to check for elevated levels of certain antibodies produced by the immune system. It's important to distinguish morphea from systemic scleroderma and other conditions. So your doctor may refer you to a specialist in skin disorders dermatologist or diseases of the joints, bones and muscles rheumatologist.