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    A classic example of this would be a limited range of motion in the wrist. At first glance, when the wrist is not moving through its full range of motion, most people assume that something is wrong with the wrist joint which is limiting it’s movement. A joint is simply a point at which two or or more bones come together and articulate or move. The bones in your lower arm join at the elbow joint and at the wrist joint. So if either one of those bones is out of alignment at the elbow joint it will not be moving correctly. This lack of motion in this single bone in your lower arm will then transfer a lack of motion to the wrist. So lack of motion in the wrist can come from a misalignment of the bones and joint in the elbow. As a member of the selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant. Originally created by Eli Lilly pharmaceutical company, dapoxetine was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the Food and Drug Administration (FDA) for the treatment of PE in 2004. Different dosage has different impacts on different types of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT and increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE.

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