If so, would you share a comment on the experience you have had with methotrexate; & the length of time on the medication, benefits noted, and side effects. It can be brief or as detailed as you desire to describe your experience. I used plaquenil for some time on its own, then added in MTX before changing over to leflunomide. Plaquenil daily dose to minimize retinopathy Plaquenil sleep disturbance Does plaquenil cause weight gain or weight loss Plaquenil make tongue eating green bannanas Dec 28, 2017 Methotrexate vs. Plaquenil - Autoimmune diseases. and thinks I should try Methotrexate. listed as one of the symptoms of Sjogren's Syndrome, but I was. Plaquenil hydroxychloroquine "I’ve been on plaquenil 400mg once a day for 6 months now due to Sjogrens. If your are wondering how long the plaquenil takes to work, it took about 3 months before I starting feeling better. Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. I would have stayed on MTX if it worked for me, but it didn’t. I didn’t drop plaquenil until I had been on a biologic for about six months. Plaquenil and methotrexate for sjogren's syndrome Treatment Options for Sjogren Syndrome Arthritis Foundation, Hydroxychloroquine User Reviews for Sjogren's Syndrome at Plaquenil difficulty sleepingWhen did doctors start prescribing chloroquin WebMD explains the causes, symptoms, and treatment of Sjogren's syndrome, a condition in which your eyes, mouth, and other parts of your body get dried out. Sjogren's Syndrome Symptoms, Causes, Diagnosis, Treatment. Ask the Expert Plaquenil and Sjögren’s. Methotrexate opinions - Symptoms and Medical Treatments - Sjogren's.. Sjögren’s Syndrome Foundation. This information was published in Arthritis Care & Research. Please visit find the most updated information about the SSF Clinical Practice Guidelines and be sure to talk to your physician about them. Hydroxychloroquine Plaquenil, a drug designed to treat malaria, is often helpful in treating Sjogren's syndrome. Drugs that suppress the immune system, such as methotrexate Trexall, also might be prescribed. Methotrexate in primary Sjögren's syndrome. Skopouli FN1, Jagiello P, Tsifetaki N, Moutsopoulos HM. Author information 1Department of Medicine, Medical School of Ioannina, Greece. OBJECTIVE To determine the safety and efficacy of methotrexate MTX in the treatment of primary Sjögren's syndrome SS.