She started me on the generic version of Plaquenil at 200 mg. I have had extreme nausea, diarrhea, stomach cramps, and intense vertigo. I began taking it on Thanksgiving day and still experience these side effects. What happens if you double doses of plaquenil Up to date chloroquine Chloroquine sulphate msds Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. For this reason, you can think of antimalarials as a sort of “lupus life insurance.” Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Yes, plaquenil is difficult to adjust first, but after the first year of treatment and side effects, the benefits outweigh the problems. So, stick with it. In my opinion, the plaque nil is keeping the immune system regulated and the pain and other symptoms described will reduce. Lupus is not an illness without pain or sacrifice, but, it’s worth it. She cut my dose in half (100 mg) and that has partially helped the symptoms. A week ago I asked if there was anything we could do and she stated that this was the only treatment pill option. Is plaquenil hard on the liver Will you have Liver function test abnormal with Plaquenil., Long-Term Side Effects of Plaquenil for Rheumatoid. Multifocal erg plaquenil Humira liver damage. which is VERY hard on the liver. As I said the plaquenil worked for me. It is pretty liver-friendly. Interesting thing about plaquenil is that in WWII, they gave it to our soldiers to prevent Malaria. Many of these soldiers reported a side effect of their joint pain lessening. Humira liver damage - MedHelp. Plaquenil side effects - kidney problems? - Symptoms.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. The trouble with liver problems is when you take prednisone or other drugs for lupus it usually hurts the liver and when you treat the Hep C it causes problems with Lupus. You have to watch both diseases and walk a fine line. My vision is blurrie and sometimes I have a hard time focusing. Pat. I get my blood tested about every 3 mos. My doc warned me about possible liver and kidney damage. I also get my retinas scanned. I am also experiencing blurred vision and problems focusing. I thought it was my contacts. I also have sjogrens so it's hard to tell. Biologics can effect your liver, but most aren't as hard on your liver as MTX - at least that is my understanding. Hopefully, this move to Plaquenil is a step to placate your insurance company so you can move to biologics.