Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. If i go off plaquenil can i go back on Can you take potassium supplements while on plaquenil How often is plaquenil taken in the population Taking cyclosporine with hydroxychloroquine can increase the amount of cyclosporine in your body. This may increase your risk of side effects from cyclosporine. Disclaimer Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person. I started on Hydroxychloroquine and prednisone at the end of December. Just saw rheumy yesterday because the prednisone wasn't having any affect on 20 mg/day and my rheumy didn't want to increase the prednisone any higher. So she has put me on methotrexate. She said I can take the dose all at one time or spread it out throughout the day. I was just letting you know how my experience with plaquenil went. Some folks take the generic w/ no problems. I take generic on most of my other meds w/ no problems. It might be too that you are being taken off the prednisone too fast. This can lead to a withdrawal syndrome if it isnt done very slowly. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Can you take prednisone with hydroxychloroquine Hydroxychloroquine Side-effects, uses, time to work, Hydroxychloroquine & Methotrexate DailyStrength Plaquenil and puffy faceHydroxychloroquine and weightlossWhat are adverse reactions for hydroxychloroquine sulfateDrug interaction zantac and chloroquine There are other side effects but they are less prevailant. Plaquenil can cause problems with eyesight, blood issues, liver and kidney damage. Unfortunately, if you do have Lupus, prednisone is your best choice to knock out the symptoms quickly. It should be given in a higher dose initially and then tapered back. Danger in taking Plaquenil and Prednisone if its not Lupus ? Yahoo.. Has anyone taken plaquenil to taper off prednisone.. Has anyone taken plaquenil to taper off prednisone - Inspire. There could be many reasons why you were put back on Prednisone. Plaquenil is a great drug I have no experience with it, but many people with lupus take it. Both pred and plaq are often prescribed together. I'd ask your rheumy about it and have them explain why they made that choice for you. Good luck! Ginny Jessie, plaquenil can take up to 6 months to take effect. I was told to not not try to discontinue any of my lupus meds while my medical condition was unstable. At the time, I had a sinus infection. Jessie, 3 years ago, my doctor discontinued my plaquenil ie. hydroxychloroquen and substituted it for an older anti-malerial drug named "chloroquin". May 12, 2008 You must also make sure to taper EXACTLY as directed by your doctor as not doing so can cause serious issues. If you are having joint pain/inflammation and kidney issues then you should take the prednisone now and continue in confirming your diagnosis of Lupus. As for the plaquenil, this is an 'old school' treatment of Lupus.