Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Who makes brand name plaquenil Sulfasalazine hydroxychloroquine and methotrexate How does h-chloroquine work for rheumatoid arthritis Hydroxychloroquine also called Talk to your doctor about this, but my guess is that the Plaquenil is not doing anything to cause the pain, but rather that it is not doing enough to prevent it. It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain. Hydroxychloroquine Plaquenil and generics can itself cause fatigue in some users, it can interrupt sleep patterns especially by causing more vivid dreams which in turn makes one more tired. The drug can also lower blood counts red cell, white cells and others too which in turn can cause fatigue. My rheumatologist just started me on plaquenil a couple of weeks ago. She said a half-dose - 200 mg because I'm skinny. My fatigue is out of control and ruining my life. I can barely hold on to my job and right after work, I fall asleep, like at 6 PM, then struggle with insomnia all night. Always feel exhausted. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil cause extreme fatigue Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis, Is lethargy and tiredness a side effect of hydroxychloroquine? Plaquenil for itpChloroquine ovarian cancer Chronic fatigue is a common RA symptom. Discover six ways you can better manage fatigue and find more energy to deal with rheumatoid arthritis. Chronic Fatigue From RA 6 Ways to Fight Back Everyday Health. Experiences taking Plaquenil for Fatigue and Muscle Pain.. Plaquenil for fatigue and pain DailyStrength. Walking up stairs, fetching groceries, or doing household chores can all make you feel like you’ve tried to climb Everest or run a marathon. You’re dizzy and lack balance. Extreme fatigue may affect a person’s sense of balance, particularly when they stand up from sitting or lying down. I appreciate all the comments and advice. I am going to talk with my RA doc about the cough at my next visit in early August. I see in the side-effect list that Plaquenil can cause the Bronchospasm, but it appears to be a very rare side effect. Still's disease systemic-onset juvenile rheumatoid arthritis is a disorder characterized by inflammation with high fever spikes, fatigue, salmon-colored rash, and/or arthritis. Though there have been several theories regarding the causes of Still's disease, the cause is not yet known.