Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Plaquenil and heart rate Plaquenil long term side effects Chloroquine is an attractive drug agent effective for the treatment of not only malaria but also inhibition of autophagy, which is a promising effect for anti-tumor therapy. Chloroquine has a particularly high affinity for melanin-containing cells and hence there are very high levels of chloroquine in the skin mainly, the epidermis and retina. Chloroquine has a long half-life, which can vary between 74 hours and 50 days, depending on the cumulative dose. Chloroquine is prescribed as both an anti‐malarial and an anti‐inflammatory drug. However, its immuno‐modulating effects remain largely unclear. Previous studies have shown that chloroquine inhibits. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Chloroquine treatment of cells Chloroquine for research Cell-culture tested InvivoGen, Chloroquine DermNet NZ Can plaquenil cause dry mouth Demonstrate that chloroquine induces vacuole forma-tion, cell death, cytosolic lipid buildup and decreased exogenous dextran uptake in ARPE-19. Results ARPE-19 Lysosomal Inhibition with Chloroquine Treatment Chloroquine is a known lysosomotropic agent that increases lysosomal pH by accumulating within lyso-somes as a deprotonated weak base. RESEARCH Open Access Chloroquine treatment of ARPE-19 cells.. Chloroquine Enhances the Number of IL‐10 Producing Cells and.. Chloroquine Uses, Side Effects & Warnings -. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Oct 01, 2018 Chloroquine phosphate tablets are indicated for the Treatment of uncomplicated malaria due to susceptible strains of P. falciparum, P.malariae, P. ovale, and P.vivax. Prophylaxis of malaria in geographic areas where resistance to Chloroquine is not present. Treatment of extraintestinal amebiasis. Chloroquine treatment of RPE cells may provide insights into the cellular mechanisms underlying AMD. Background. Age-Related Macular Degeneration AMD is the leading cause of progressive central vision loss in elderly people over the age of 60 1-3.