While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta. Chloroquine resistance prophylaxis Plaquenil financial assistance Saltwater fish chloroquine compatible with meteoplex Chloroquine hydrochloride Injection 50 mg/ml 40 mg/ml base chloroquine phosphate Tablets 250 mg 150-mg base; 500 mg 300-mg base Indications and dosages Suppressive prophylaxis. Adults 500 mg 300-mg base P. O. on same day once weekly beginning 2 weeks before exposure. Chloroquine is not embryo- and fetotoxic when used at the usual dose for malaria prophylaxis or for a three-day treatment of a typical malaria attack McGready 2002, Phillips-Howard 1996. Current evidence does not suggest fetal ocular toxicity when chloroquine was used as antimalarian medication during pregnancy review by Osadchy 2011. Low dose prednisolone 2, azathioprine 5, and /or hydroxychloroquine 6 - 8 as these have proved safe and efficacious in pregnancy 5. Hydroxychloroquine in particular is associated with improved obstetric outcomes in SLE 9. Chloroquine, although grouped with hydroxychloroquine in table 2 of this article, is not routinely used in the Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area. Chloroquine dose during pregnancy Chloroquine Injection Uses, Side Effects, Interactions., Chloroquine - an overview ScienceDirect Topics Weight based dosing plaquenilHydroxychloroquine keratopathyBiaxin and plaquenil lyme diseaseHydroxychloroquine for sle Hydroxychloroquine Pregnancy Warnings Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. Hydroxychloroquine Use During Pregnancy. Treatment of SLE in pregnancy and use of Chloroquine The BMJ. CHLOROQUINE PHOSPHATE, USP. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection Author links open overlay panel Olusola Olafuyi 1 Raj K. S. Badhan 1 2 Show more There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women. Usage of chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgment of the physician the benefit outweighs the potential risk to the fetus. REFERENCES. 1.