Summary Description and Clinical Pharmacology Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage, Contraindications, Other Rx Info Active Ingredients User Ratings / Reviews Side Effect Reports Cymbalta is indicated for the treatment of major depressive disorder (MDD). The efficacy of Cymbalta was established in four short-term and one maintenance trial in adults. [see Clinical Studies ()] 14.1 A major depressive episode (DSM-IV) implies a prominent and relatively persistent (nearly every day for at least 2 weeks) depressed or dysphoric mood that usually interferes with daily functioning, and includes at least 5 of the following 9 symptoms: depressed mood, loss of interest in usual activities, significant change in weight and/or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, or a suicide attempt or suicidal ideation. Cymbalta is indicated for the treatment of generalized anxiety disorder (GAD). The efficacy of Cymbalta was established in three short-term trials and one maintenance trial in adults. [see Clinical Studies ()] 14.2 Generalized anxiety disorder is defined by the DSM-IV as excessive anxiety and worry, present more days than not, for at least 6 months. The excessive anxiety and worry must be difficult to control and must cause significant distress or impairment in normal functioning. Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. It thus did not recommend duloxetine as a first line treatment for major depressive disorder, given the (then) high cost of duloxetine compared to inexpensive off-patent antidepressants and lack of increased efficacy. do not list duloxetine among the recommended treatment options. A review from the Annals of Internal Medicine lists duloxetine among the first line drug treatments, however, along with citalopram, escitalopram, sertraline, paroxetine, and venlafaxine. Zoloft pmdd Propranolol dose anxiety Cymbalta is indicated for the treatment of major depressive disorder MDD. The efficacy of Cymbalta was established in four short-term and one maintenance. Medscape - Generalized anxiety disorder, major depressive disorder, fibromyalgia-specific dosing for Cymbalta duloxetine, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Duloxetine brand names Cymbalta, Yentreve, and in parts of Europe. 60 mg/1, Oral, Lake Erie Medical Surgical & Supply DBA Quality Care Products LLC. Duloxetine (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly and Company. Duloxetine has not yet been FDA approved for stress urinary incontinence or for fibromyalgia. Duloxetine is a selective SNRI (selective serotonin-norepinephrine reuptake inhibitor). Duloxetine is a systemic drug therapy which affects the body as a whole. Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE- and 5-HT transporter sites. It is a less potent inhibitor of dopamine reuptake. The NICE British National Formulary (BNF) and British National Formulary for Children (BNFc) sites are only available to users in the UK, Crown Dependencies and British Overseas Territories. If you believe you are seeing this page in error please contact us. Duloxetine how supplied Duloxetine Oral Uses, Side Effects, Interactions, Pictures., Cymbalta duloxetine dosing, indications, interactions. Hong kong cialis Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for DULOXETINE. DULOXETINE Drug BNF content published by NICE. Duloxetine DB00476 - Duloxetine - DrugBank. Cymbalta duloxetine hydrochloride capsules - FDA. Cymbalta safely and effectively. See full prescribing information for Cymbalta. Cymbalta duloxetine hydrochloride Delayed-Release Capsules for Oral. Indications and Usage, Generalized Anxiety Disorder 1.2 11/2009 Indications and Usage, Chronic Musculoskeletal Pain 1.5 10/2010 Doctors agreed Multiple uses Cymbalta duloxetine is an "antidepressant" medication. However, it is an approved treatment for a variety of indications to include unipolar depression, anxiety, and chronic pain related to diabetic neuropathy, musculoskeletal and/or fibromyalgia. CYMBALTA Duloxetine Delayed-Release Capsules for Oral Use. disorders. In addition, do not start CYMBALTA in a patient who is. being treated with linezolid or intravenous methylene blue 4 Initial U. S. Approval 2004. INDICATIONS AND USAGE ----- CYMBALTA ® is a serotonin and norepinephrine reuptake inhibitor.