Methotrexate is one of the most commonly used drugs to treat RA. However, it can decrease the levels of an important vitamin in your body called folate. Chloroquine phosphate sds Plaquenil methotrexate Hi. I take 20 mg of Methotrexate weekly, 3 mg of folic acid daily, & 400 mg of Plaquenil daily. The Methotrexate makes me extremely nauseous. I think it causes more hair loss although it hard to tell since Lupus & Hashimoto’s also cause hair loss. The good news These common side effects can often be short-circuited by taking a folic acid supplement. Folic acid is the synthetic form of folate. One study found that rheumatoid arthritis RA patients on methotrexate who took folic acid supplements lowered the risk of GI problems and mouth sores by 79 percent. Background 34 year old mother of 2 diagnosed in December with RA high RF and Anti-CCP. I'm on methotrexate injections just recently increased to 20 mg and plaquenil 200 mg twice a day. And folic acid. Early December I received a steroid injection to help with the pain/inflammation and improve my mobility temporarily. Your doctor may suggest you take a folic acid supplement, which is a manufactured form of folate. This leads to a side effect of methotrexate called folate deficiency. Methotrexate and folic acid and plaquenil for lupus Methotrexate - Kaleidoscope Fighting Lupus, Methotrexate Managing Side Effects Arthritis Foundation Sjogren's hydroxychloroquine 44Mylan hydroxychloroquine highPlaquenil co pay card Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Methotrexate vs Plaquenil Comparison -. Side effects plaquenil/methotrexate. rheumatoid. Methotrexate and plaquenil - @Kristinsaba1988 - Scleroderma.. Has anyone experienced any hair loss while on Methotrexate? I'm currently on 10mg once a week and have noticed an increase in hair loss. My doctor has also increased my folic acid dosage in hopes with helping it. I'm getting married in the fall and don't want to be bald by that day. A weekly dose of methotrexate can cause unpleasant side effects, so Dooley recommends taking it when you have a couple of days off. For example, on Fridays, if you work during the week. “If you don’t feel 100 percent afterward, you have the weekend to get through it,” she says. It’s also important to avoid alcohol while taking methotrexate. My rheumy has had me on a 1000 IU of Vit D 3 times a day plus I took Folic Acid while on Methotrexate. I've taken a full regimen of vitamins for decades & kept them up so far throughout my Lupus. I fully believe that it's a large part of what keeps me in good balance.