It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Plaquenil eye grib waves Drug category for hydroxychloroquine For children, sulfasalazine should only be started by a specialist. Sulfasalazine won’t start to work immediately, and it could be at least 12 weeks before you notice any effects. You shouldn’t take sulfasalazine if you’re known to have an allergy to salicylates. Salicylate is a natural chemical that is found in some foods. Plaquenil hydroxychloroquine is considered an older DMARD disease modifying anti-rheumatic drug. Plaquenil was actually first classified as an antimalarial drug, but it is also used to treat certain rheumatic and autoimmune conditions which are unrelated to malaria. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Azulfidine Sulfasalazine is used to treat moderate to severe inflammatory bowel conditions. It's also used with other medicines to treat rheumatoid arthritis. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. What to use when plaquenil and sulfasalazine doesn't work What are the side effects of hydroxychloroquine and., Taking Plaquenil for Rheumatoid Arthritis Ra treatments plaquenil Hey everyone! Is anyone here with psoriatic arthritis just taking plaquenil or sulfasalazine or both together? I’m curious to know if these drugs can individually or mutually be enough to control inflammatory symptoms. Any success with plaquenil or sulfasalazine? PsoriaticArthritis. Compare Plaquenil vs Sulfasalazine -. Combination therapy with sulfasalazine and methotrexate is more.. Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. Hydroxychloroquine doesn’t work immediately. It may be 12 weeks or longer before you notice any benefit. Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side-effects even if it doesn't seem to be working at first; even when your symptoms improve to help keep the disease under. I am a 72 year old female, diagnosed with RA 6 years ago. I took Plaquenil 200x2 from 2012-2016, along with Prednisone to start. Due to the fact, I could not use my hands because of the swelling, I risked the possible vision problems. By 2012, symptom free and still fearful of vision loss, I stopped the drug.