Number needed to treat hydroxychloroquine

Discussion in 'Canadian Pharmaceuticals Online' started by overload, 20-Mar-2020.

  1. patrik New Member

    Number needed to treat hydroxychloroquine


    Lupus medications can help lower long-term risks and keep symptoms under control. According to the Lupus Foundation of America, 80% to 90% of people with lupus can expect a normal lifespan with good treatment. In the 1950s, most people with lupus died within a few years of diagnosis. A combination of earlier diagnosis, better lupus medications, and more aggressive treatment, says Lisa Fitzgerald, MD, assistant professor of medicine at Harvard Medical School.

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    Hydroxychloroquine is also used to treat symptoms of acute or chronic rheumatoid arthritis and lupus erythematosus. Adult doses range from 400 mg/week for suppressive therapy to 1,200 mg/day for acute malaria attacks. Typical daily doses of 200 to 600 mg are used for lupus and rheumatoid diseases. The number needed to treat NNT is the number of patients who need a specific treatment to prevent one additional bad outcome eg, myocardial infarction, stroke. The NNT specifies the treatment, its duration and the adverse outcome being prevented. The Number Needed to Treat NNT is the number of patients you need to treat to prevent one additional bad outcome death, stroke, etc. For example, if a drug has an NNT of 5, it means you have to treat 5 people with the drug to prevent one additional bad outcome.

    "I want people to have the same level of functioning that they had before they got sick," Bermas tells Web MD. Now, the goal of lupus treatment is not just to reduce the symptoms, but to maintain full function, says Bonnie Lee Bermas, MD, director of the Brigham and Women's Hospital Lupus Center in Boston.

    Number needed to treat hydroxychloroquine

    Plaquenil - Uses, Side Effects, Interactions -, Numbers Needed To Treat. Medical statistic information Patient

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  4. Dosing Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Using this formula, the dosage for a 150-pound person would be 443 mg/day, as one kilogram equals 2.2 pounds. Because HCQ is formulated as a 200 mg tablet, many people taking it for lupus will take two pills per day.

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    Generally, hydroxychloroquine is given in 200 mg or 400 mg doses, once per day. Higher doses can sometimes be used, but only in adults and not for all cases. Hydroxychloroquine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever, chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Hydroxychloroquine is being considered globally as an economical and effective treatment for COVID-19. The drug is most commonly used to treat malaria and rheumatic diseases.

     
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    Experience with plaquenil? — Lupus Research Community I think if you can get a good anti-nausea Drug until your body figures out what going on. Vomiting, loss of appetite, fatigue,and muscle wasting took no time in the 8 weeks that it took to figure out what was up. It took me almost 8 weeks to figure out how to take plaquenil. Now my body doesn’t revolt.

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