It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. How does plaquenil affect sleep Lupus plaquenil prednisone Oct 15, 2008 Do you know what your baseline creatinine was? It can be tricky. Although it is in the normal range, a rise can be concerning. Having said that, my creatnine is 8 and my bun is 67 has been in the hundreds. If your doc thinks the cellcept is causing the rise, several meds can, it should go back to your base when the meds are stopped. Because renal clearance of hydroxychloroquine does not correlate with creatinine clearance, dosage adjustments are not required in patients with renal impairment. However, a dosage reduction may be necessary in patients with renal disease or in patients with concomitant medications known to affect the kidney. Despite optimization of renin-angiotensin-aldosterone system RAAS inhibition, patients with immunoglobulin A nephropathy IgAN and persistent proteinuria remain at risk for kidney failure. We evaluated the efficacy and safety of hydroxychloroquine HCQ, an immunomodulator, when added to the treatment regimen of patients with IgAN. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil and creatinine Hydroxychloroquine Side Effects, Dosage, Uses, and More, Plaquenil hydroxychloroquine sulfate dose, indications. Can hydroxychloroquine help osteoarthritisHydroxychloroquine and blood pressure Hydroxychloroquine is an antimalarial agent that tradi-tionally has been used to treat mucocutaneous, musculo-skeletal, serosal, and constitutional manifestations of SLE. Previous studies from our group and others have shown that hydroxychloroquine usage is associated with a re-duced risk of damage accrual 10, improved survival Protective Effect of Hydroxychloroquine on Renal Damage in Patients.. Effects of Hydroxychloroquine on Proteinuria in IgA.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. I did have side effects to Plaquenil. The best way I can describe it is that my legs felt like noodles that were ready to give way underneath me. My muscles ached and felt very weak. It is a rare side effect of Plaquenil and the doctors did not believe me, but I know that it stopped as soon as I stopped the plaquenil. Plaquenil ®. Range for renal clearance of unchanged drug was approximately 16 to 30% and did not correlate with creatinine clearance; therefore, a dosage adjustment is not required for patients with renal impairment. In RA patients, there was large variability as to the fraction of the dose absorbed i.e. 30 to 100%, and mean. PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects.