Doxycycline off label use

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    Doxycycline off label use


    When penicillin is contraindicated, doxycycline is an alternative drug in the treatment of the following infections: -Syphilis caused by Treponema pallidum -Yaws caused by Treponema pallidum subspecies pertenue -Listeriosis due to Listeria monocytogenes -Vincent’s infection caused by Fusobacterium fusiforme -Actinomycosis caused by Actinomyces israelii -Infections caused by Clostridium species CDC STD guidelines: MMWR Recomm Rep. June 5, 20(RR3);1-137 Uncomplicated gonococcal infection of the cervix, urethra, and rectum: Ceftriaxone 250 mg IM once plus azithromycin 1 g PO once (preferred) or alternatively doxycycline 100 mg PO q12hr for 7 days Uncomplicated urethral, endocervical, or rectal infection caused by Chlamydia trachomatis: 100 mg PO BID x 7 days Nongonococcal urethritis caused by C. urealyticum: 100 mg PO BID x 7 days Syphilis (early): Patients who are allergic to penicillin should be treated with doxycycline 100 mg PO BID x 2 weeks Syphilis 1 year duration: Patients who are allergic to penicillin should be treated with doxycycline 100 mg PO BID x 4 weeks Acute epididymo-orchitis caused by N. gonorrhoeae or C trachomatis: 100 mg PO BID x least 10 days Equivalent dose of Doryx MPC is 120 mg PO BID Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated as judged by immunofluorescence; also approved for inclusion conjunctivitis caused by chlamydia trachomatis 100 PO q12hr on day 1, then 100 mg PO q Day Equivalent dose of Doryx MPC is 120 mg PO q12h on day 1, then 120 mg PO q Day Indicated for Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox, and tick fevers caused by Rickettsiae 100 PO q12hr on day 1, then 100 mg PO q Day Equivalent dose of Doryx MPC is 120 mg PO q12h on day 1, then 120 mg PO q Day Suspected Bartonella infection with a negative culture: 100 mg PO BID x 6 weeks in combination with gentamicin and ceftriaxone Positive culture Bartonella infection: 100 mg PO BID x 6 weeks in combination with gentamicin or rifampin Equivalent dose of Doryx MPC is 120 mg PO BID Single dose: 7 mg/kg PO/IV; not to exceed 300 mg/dose; adjunct to fluid and electrolyte replacement Multiple dose: 2 mg/kg PO/IV twice daily on day 1; THEN, 2 mg/kg q Day on days 2 and 3; not to exceed 100 mg/dose; adjunct to fluid and electrolyte replacement Anorexia Dental discoloration Diarrhea Dysphagia Enterocolitis Erythema multiform Esophageal ulcer Esophagitis Exacerbation of systemic lupus erythematosus Exfoliative dermatitis Glossitis Headache Hemolytic anemia Hepatotoxicity Hypoglycemia Inflammatory anogenital lesion Intracranial hypertension Nausea Neutropenia Pericarditis Serum sickness Skin hyperpigmentation Toxic epidermal necrolysis Thrombocytopenia Upper abdominal pain Urticaria Vomiting Drug rash with eosinophilia and systemic symptoms Not drug of choice for any staphylococcal infection Risk of thrombophlebitis when given IV History of candidiasis overgrowth Hepatotoxicity may occur; if symptoms occur, measure LFTs and discontinue drug Photosensitivity may occur with prolonged exposure to sunlight or tanning equipment; reduce dose in renal impairment May increase BUN due to its anti-anabolic effects; use caution in patients with renal impairment Consider drug serum level determinations in prolonged therapy Tetracycline use during tooth development (last half of pregnancy through age 8 years) can cause permanent discoloration of teeth; use doxycycline in pediatric patients 8 years of age or less only when potential benefits expected to outweigh risks in severe or life-threatening conditions (e.g., anthrax, Rocky Mountain spotted fever); particularly when there are no alternative therapies Superficial discoloration of adult permanent dentition, reversible upon drug discontinuation and professional dental cleaning has reported; permanent tooth discoloration and enamel hypoplasia may occur with drugs of tetracycline class when used during tooth development Fanconi-like syndrome may occur with outdated tetracyclines Intracranial hypertension (pseudotumor cerebri) reported (rare) may occur; symptoms include headache, blurred vision, diplopia, and vision loss; papilledema can be found on funduscopy; women of childbearing age who are overweight or have a history of IH are at greater risk; possibility for permanent visual loss exists; if visual disturbance occurs during treatment, prompt ophthalmologic evaluation is warranted; intracranial pressure can remain elevated for weeks after drug cessation; monitor patients until they stabilize Doxycycline offers substantial but not complete suppression of asexual blood stages of Plasmodium strains; doxycycline does not suppress P. falciparum’s sexual blood stage gametocytes; subjects completing prophylactic regimen may still transmit infection to mosquitoes outside endemic areas Prolonged use may result in superinfection Overgrowth of non-susceptible organisms, including fungi, may occur; if such infections occur, discontinue use and institute appropriate therapy May induce hyperpigmentation in many organs including skin, eyes, nails, thyroid and bone If Clostridium difficile associated diarrhea suspected or confirmed, may need to discontinue ongoing antibacterial use not directed against C. difficile; may also need to institute appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C. difficile, and surgical evaluation as clinically indicated Use in pediatric patients 8 years of age or less only when potential benefits are expected to outweigh risks in severe or life-threatening conditions (e.g., anthrax, Rocky Mountain spotted fever), particularly when there are no alternative therapies Severe skin reactions, such as exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS) reported; if severe skin reactions occur, discontinue therapy immediately and institute appropriate therapy Not studied in pregnant patients; the vast majority of reported experience with doxycycline during human pregnancy is short-term, first trimester exposure; there are no human data available to assess effects of long-term therapy of doxycycline in pregnant women, such as that proposed for treatment of anthrax exposure; it should not be used in pregnant women unless, in judgment of physician, it is essential for welfare of patient; evidence of embryotoxicity has been noted in animals treated early in pregnancy Tetracyclines are excreted in human milk; however, extent of absorption of tetracyclines, including doxycycline, by breastfed infant is not known; short-term use by lactating women is not necessarily contraindicated; however, effects of prolonged exposure to doxycycline in breast milk are unknown;11 because of potential for serious adverse reactions in nursing infants from doxycycline, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account importance of drug to mother Inhibits protein synthesis and, thus, bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria; may block dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest. Solution: D5W, NS Additive: Ranitidine Syringe: Doxapram Y-site (partial list): Acyclovir, amiodarone, aztreonam, hydromorphone, linezolid, Mg SO4, meperidine, meropenem (comp at 1 mg/m L mero and 1 mg/m L doxy; incomp at 50 mg/m L mero and 1 mg/m L doxy), morphine SO4, propofol, remifentanil The above information is provided for general informational and educational purposes only. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product Capsule, Oral, as hyclate [strength expressed as base]: Morgidox: 50 mg, 100 mg [contains brilliant blue fcf (fd&c blue #1)]Vibramycin: 100 mg [contains brilliant blue fcf (fd&c blue #1)]Generic: 50 mg, 100 mg Capsule, Oral, as monohydrate [strength expressed as base]: Adoxa: 150 mg [DSC] [contains fd&c red #40, fd&c yellow #6 (sunset yellow)]Mondoxyne NL: 50 mg [contains fd&c yellow #10 (quinoline yellow)]Mondoxyne NL: 75 mg [DSC]Mondoxyne NL: 75 mg, 100 mg [contains fd&c yellow #10 (quinoline yellow)]Monodox: 75 mg [DSC], 100 mg [DSC]Okebo: 75 mg, 100 mg [DSC]Generic: 50 mg, 75 mg, 100 mg, 150 mg Capsule Delayed Release, Oral, as monohydrate [strength expressed as base]: Oracea: 40 mg Generic: 40 mg Kit, Combination, as hyclate [strength expressed as base]: Alodox Convenience: 20 mg [DSC]Morgidox: 1 x 50 mg, 2 x 100 mg, 1 x 100 mg [contains brilliant blue fcf (fd&c blue #1), cetyl alcohol, edetate disodium]Ocudox: 50 mg [DSC] [contains brilliant blue fcf (fd&c blue #1)]Kit, Oral, as monohydrate [strength expressed as base]: Nic Azel Doxy 30: 100 mg [DSC] [contains brilliant blue fcf (fd&c blue #1), fd&c yellow #10 aluminum lake, fd&c yellow #6 (sunset yellow), fd&c yellow #6 aluminum lake, tartrazine (fd&c yellow #5)]Nic Azel Doxy 60: 100 mg [DSC] [contains brilliant blue fcf (fd&c blue #1), fd&c yellow #10 aluminum lake, fd&c yellow #6 (sunset yellow), fd&c yellow #6 aluminum lake, tartrazine (fd&c yellow #5)]Solution Reconstituted, Intravenous, as hyclate [strength expressed as base, preservative free]: Doxy 100: 100 mg (1 ea)Generic: 100 mg (1 ea)Suspension Reconstituted, Oral, as monohydrate: Generic: 25 mg/5 m L (60 m L)Suspension Reconstituted, Oral, as monohydrate [strength expressed as base]: Vibramycin: 25 mg/5 m L (60 m L) [contains brilliant blue fcf (fd&c blue #1), methylparaben, propylparaben; raspberry flavor]Generic: 25 mg/5 m L (60 m L)Syrup, Oral, as calcium [strength expressed as base]: Vibramycin: 50 mg/5 m L (473 m L) [contains butylparaben, propylene glycol, propylparaben, sodium metabisulfite; raspberry-apple flavor]Tablet, Oral, as hyclate [strength expressed as base]: Acticlate: 75 mg [contains brilliant blue fcf (fd&c blue #1), fd&c yellow #6 (sunset yellow)]Acticlate: 150 mg [scored; contains fd&c blue #2 (indigotine)]Targa DOX: 50 mg [contains fd&c blue #2 (indigotine), fd&c yellow #6 (sunset yellow)]Generic: 20 mg, 50 mg, 75 mg, 100 mg, 150 mg Tablet, Oral, as monohydrate [strength expressed as base]: Adoxa: 50 mg [DSC]Adoxa: 75 mg [DSC] [contains fd&c yellow #10 aluminum lake, fd&c yellow #6 (sunset yellow)]Adoxa: 100 mg [DSC]Adoxa Pak 1/100: 100 mg [DSC] [contains fd&c yellow #10 aluminum lake, fd&c yellow #6 (sunset yellow)]Adoxa Pak 2/100: 100 mg [DSC] [contains fd&c yellow #10 aluminum lake, fd&c yellow #6 (sunset yellow)]Adoxa Pak 1/150: 150 mg [DSC] [scored; contains fd&c yellow #6 (sunset yellow)]Avidoxy: 100 mg [contains fd&c yellow #10 aluminum lake, fd&c yellow #6 aluminum lake]Generic: 50 mg, 75 mg, 100 mg, 150 mg Tablet Delayed Release, Oral, as hyclate [strength expressed as base]: Doryx: 50 mg, 200 mg [DSC]Doryx: 200 mg [scored]Doryx MPC: 120 mg [contains corn starch]Soloxide: 150 mg [scored]Generic: 50 mg, 75 mg, 100 mg, 150 mg, 200 mg Inhibits protein synthesis by binding with the 30S and possibly the 50S ribosomal subunit(s) of susceptible bacteria; may also cause alterations in the cytoplasmic membrane20 mg tablets and capsules (Periostat [Canadian product]): Proposed mechanism: Has been shown to inhibit collagenase activity in vitro. Also has been noted to reduce elevated collagenase activity in the gingival crevicular fluid of patients with periodontal disease. Systemic levels do not reach inhibitory concentrations against bacteria. Oral: Almost completely from the GI tract; average peak plasma concentration can be reduced by high-fat meal or milk by ~20% (30% for Doryx MPC) Widely distributed into body tissues and fluids including synovial, pleural, prostatic, seminal fluids, and bronchial secretions; saliva, aqueous humor, and CSF penetration is poor Not hepatic; partially inactivated in GI tract by chelate formation Feces (30%); urine (23% to 40%) Serum: Oral: Immediate release: 1.5 to 4 hours; delayed-release tablets: 2.8 to 3 hours 18 to 22 hours; End-stage renal disease: 18 to 25 hours . Based on the American College of Chest Physicians diagnosis and management of lung cancer clinical practice guidelines, intrapleural doxycycline is effective and recommended in the management of recurrent, symptomatic, malignant pleural effusions. Based on the Centers for Disease Control and Prevention (CDC) sexually transmitted diseases treatment guidelines, doxycycline in combination with ceftriaxone is an effective and recommended agent in the treatment of acute proctitis or proctocolitis.

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    How to use Doxycycline Hyclate Tablet Tetracyclines. This medication is best taken by mouth on an empty stomach, at least 1 hour before or 2 hours after a meal. Oct 18, 2011. Although an initial open-label study using minocycline in. users and 100 side effects reported by 57 out of 484 11.8% doxycycline users. Looking for online definition of doxycycline monohydrate in the Medical Dictionary? doxycycline. Off-label uses. doxycycline monohydrate; doxycycline polymer.

    Doxycycline is an antibiotic drug that kills a wide, weird and wonderful range of bugs that are often difficult to treat with other antibiotics. These include bacteria and parasites that take up residence inside our cells (called “intracellular organisms”), making them hard for most antibiotics to reach. Unlike many other antibiotics, doxycycline penetrates deep into our tissues and ends up inside our cells, where it can kill these bugs. Examples of intracellular organisms susceptible to doxycycline include numerous “zoonotic infections” (infections that are spread from animals to humans), chlamydia, legionella (the cause of legionnaire’s disease) and malaria. Other susceptible microorganisms include “spirochaetes” (that can cause syphilis and Lyme disease) and the bacteria that cause acne, anthrax and cholera. Doxycycline interferes with a microorganism’s ability to manufacture proteins – the “building blocks” of life. Protein manufacture occurs in a part of the cell called the “ribosome” and is fundamental to any organism’s survival. In addition to the general indications for all members of the tetracycline antibiotics group, doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease, Moraxella catarrhalis, Brucella melitensis, Chlamydia pneumoniae, and Mycoplasma pneumoniae are generally susceptible to doxycycline, while some Haemophilus spp., Mycoplasma hominis, and Pseudomonas aeruginosa have developed resistance to varying degrees. Some Gram-positive bacteria have developed resistance to doxycycline. Up to 44% of Streptococcus pyogenes and up to 74% of S. faecalis specimens have developed resistance to the tetracycline group of antibiotics. When bacteriologic testing indicates appropriate susceptibility to the drug, doxycycline may be used to treat these infections caused by Gram-positive bacteria: The World Health Organization Guidelines states that the combination of doxycycline with either artesunate or quinine may be used for the treatment of uncomplicated malaria due to Plasmodium falciparum or following intravenous treatment of severe malaria. Doxycycline kills the symbiotic Wolbachia bacteria in the reproductive tracts of parasitic filarial nematodes, making the nematodes sterile, and thus reducing transmission of diseases such as onchocerciasis and elephantiasis. Doxycycline has been used successfully to treat sexually transmitted, respiratory, and ophthalmic infections.

    Doxycycline off label use

    Doxycycline Doryx -, Minocycline and doxycycline therapy in community patients with.

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  5. Updated Physician’s Guide to the Off-label Uses of. many of its off-label uses continue to go. double-blind comparison study against doxycycline.

    • Updated Physician’s Guide to the Off-label. - PubMed Central..
    • Doxycycline monohydrate definition of. - Medical Dictionary.
    • Doxycycline Antibiotics for Birds - VetDepot.

    Dec 20, 2016. Doxycycline is an antibiotic drug that kills a wide, weird and wonderful range. Its most widespread use as prophylaxis is for tourists and other. Primary Care Optometry News J. James Thimons The off-label use of oral antibiotics can. However, when using the cycline class of antibiotics, a practitioner must be. Doxycycline is an especially useful cycline antibiotic for the treatment of. May 19, 2015. Here is a look at doxycycline and its plethora of uses. Doxycycline is also commonly used off-label for a number of other infections, including.

     
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