Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss. The mechanism of this toxicity is not clearly understood, though it is believed that the drug molecule binds to melanin in the retinal pigment epithelium (RPE). Plaquenil contraindications ativan Chloroquine injection Plaquenil causing lymphoma Rheumatoid arthritis is a chronic inflammatory disease characterized by uncontrolled proliferation of synovial tissue and a wide array of multisystem comorbidities. Prevalence is estimated to be 0. Systemic lupus erythematosus is a disease that continues to evolve over time. Thus, a patient who presents with skin and joint disease remains at risk for renal disease even after having lupus. Retinal toxicity is found among people who take Plaquenil, especially for people who are female, 40-49 old, have been taking the drug for 5 - 10 years, also take medication Arava, and have Osteoporosis Binding of the drug to melanin in the RPE contributes to, or prolongs, its toxic effects. This leads to disruption and damage to the photoreceptors and outer nuclear and plexiform layer, sparing the foveal center and resulting in the “bull’s eye” appearance in the late stage of the disease. Retinal toxicity and plaquenil aafp Optometric Management - The Many Faces of a Retinal Hemorrhage, Treatment of Systemic Lupus Erythematosus An Update. Chloroquine ncbiLysosomal swelling by chloroquineChloroquine and paludrine in pregnancyLupus and plaquenil problemsWhat tier is hydroxychloroquine After seeing MANY professionals including a neurologist, a retinal specialist, neuro-ophthalmologist, and undergoing MANY different tests, she was diagnosed with Plaquenil toxicity. She does have field of vision loss, mostly on things that are close up. She took Plaquenil for almost five years before having any symptoms. Has anyone experienced plaquenil toxicity with damage to eyes?. Will you have Retinal toxicity with Plaquenil - eHealthMe. Protecting your eyesight when taking Plaquenil Lupus.. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1is now considered for new disease applications in diabetes, heart disease and adjunct. Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. Retinal toxicity was diagnosed on the basis of the automated perimetry results of the central 10° of vision and spectral domain optical coherence tomography. The associations between the demographic and clinical factors and retinal toxicity were assessed, and P 0.05 was considered statistically significant.