In a randomized, open-label, multicenter prophylaxis trial, 221 nonimmune pediatric travelers (age, 2–17 years) received either atovaquone-proguanil or chloroquine-proguanil. Safety and clinical outcome were evaluated 7, 28, and 60 days after travel. Plaquenil congestive heart failure Plaquenil plm Aao plaquenil dosing Hepatotoxicity, which is uncommon with either chloroquine or proguanil, has been reported after the use of a fixed-dose combination of chloroquine and proguanil 2 A. A day before visiting the Indian subcontinent a 50-year-old French Caucasian woman began a course of a fixed-dose combination of proguanil 200 mg + chloroquine 100 mg, one. Adults Four MALARONE Tablets adult strength; total daily dose 1 g atovaquone/400 mg proguanil hydrochloride as a single daily dose for 3 consecutive days. Pediatric Patients The dosage for treatment of acute malaria in pediatric patients is based upon body weight Table 2. Non-chloroquine-resistant. 1 g 600 mg base PO, THEN; 500 mg 300 mg base PO 6-8 hours later, THEN; 500 mg 300 mg base PO at 24 hours & 48 hours after initial dose; Amebiasis, Extraintestinal. 1 g 600 mg base PO qDay for 2 days, THEN. 500 mg 300 mg base qDay for 14-21 days. Porphyria Cutanea Tarda Off-label 125-250 mg 75-150 mg base PO twice weekly The data indicate that, over the course of treatment, fewer atovaquone-proguanil recipients had treatment-related adverse events (8% vs. Two subjects discontinued prophylaxis because of drug-related adverse events; both had received chloroquine-proguanil. By posttravel day 7, a total of 39 (35%) of 110 atovaquone-proguanil and 41 (37%) of 111 chloroquine-proguanil recipients reported ⩾1 adverse event. Chloroquine proguanil dose Proguanil and Chloroquine - NPA NPA, Malarone Atovaquone and Proguanil Hcl Uses, Dosage. Hydroxychloroquine uses lupusChloroquine dosage Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart. Chloroquine Dosage Guide with Precautions -. Aralen, Chloroquine phosphate chloroquine dosing.. Chloroquine - FDA prescribing information, side effects and uses. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chloroquine is very toxic in overdose - parents must take special care to store the tablets safely. It is generally accepted, as a result of long usage, to be safe in pregnancy. Proguanil. Patient Information Leaflet PIL for proguanil. Licensed for prophylaxis in UK. Preparations available Paludrine® Zeneca. Adult dose is 200mg daily. Dosage The standard dose for adults over 45kg is two tablets of Chloroquine and 2 tablets of Proguanil. How to take Start taking Chloroquine one week before entering the malaria risk area. For Proguanil it is sufficient to start taking the tablets 2 days before entering the risk area.