Tamoxifen risks

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  1. Tiger-Kitty Guest

    Tamoxifen risks


    For women with a higher than average risk of breast cancer, some medicines can help reduce this risk. But these drugs can also have side effects, so it’s important to weigh their pros and cons before deciding whether to take one. Taking medicines to help lower the risk of getting a disease is called . The most commonly used medicines to lower breast cancer risk are tamoxifen and raloxifene. Other medicines called aromatase inhibitors (such as anastrozole and exemestane) might also be options. The first step in deciding if you should take a drug to help lower your chances of getting breast cancer is to have a health care provider assess your breast cancer risk. (See below for names of tools that can be used to do this.) For now, most experts say that your breast cancer risk should be higher than average for you to consider taking one of these drugs. Tamoxifen and raloxifene have been shown to reduce the risk breast cancer, but they can have their own risks and side effects. Tamoxifen and raloxifene are the only drugs that are approved in the US to help lower the risk of breast cancer, although for some women, drugs called aromatase inhibitors might be an option as well. This means that they act against (or block) estrogen (a female hormone) in some tissues of the body, but act like estrogen in others. Estrogen can fuel the growth of breast cancer cells. Tamoxifen can be taken whether or not you have gone through menopause, but raloxifene is only approved for post-menopausal women. Both of these drugs block estrogen in breast cells, which is why they can be useful in lowering breast cancer risk. To lower the risk of breast cancer, these drugs are taken for 5 years. The effect of these drugs on breast cancer risk has varied in different studies. When the results of all the studies are taken together, the overall reduction in risk for these drugs is about 40% (more than a third). These drugs lower the risk of both invasive breast cancer and ductal carcinoma in situ (DCIS). Although a medicine that cuts your risk by about 40% sounds like it must be a good thing, what it would really mean for you depends on how high your risk is in the first place (your baseline risk).

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    Jan 16, 2019. Tamoxifen is a common medication used to prevent recurrence of breast cancer. Learn about the side effects, risks, drug interactions, and more. Dec 3, 2014. Tamoxifen can decrease risk of invasive breast cancer up to 48% and was US Food and Drug Administration FDA–approved for primary. QUESTION In women with an increased risk of breast cancer, does tamoxifen reduce the risk of breast cancer and what are the associated harms?

    Tamoxifen won't work on hormone-receptor-negative breast cancer. Tamoxifen is available in two forms: a pill taken once a day (brand name: Nolvadex) or a liquid form (brand name: Soltamox). If you dislike pills or you're having trouble swallowing tamoxifen pills, Soltamox can help make it easier to stay on your treatment plan. Most doctors recommend taking tamoxifen at the same time each day. — while you are taking tamoxifen and for 2 months afterward. You should not take tamoxifen if you are breastfeeding, pregnant, trying to get pregnant, or if there is any chance that you could be pregnant. You should use an effective non-hormonal type of birth control — such as condoms, a diaphragm along with spermicide, or a non-hormonal I. Ask your doctor which type of non-hormonal birth control would be best for you. Since its approval in 1998, tamoxifen has been used to treat millions of women and men diagnosed with hormone-receptor-positive breast cancer. While an aromatase inhibitor is the first hormonal therapy medicine choice for postmenopausal women, tamoxifen is the first choice for premenopausal women and is still a good choice for postmenopausal women who can't take an aromatase inhibitor. BACKGROUND: In response to findings from the Breast Cancer Prevention Trial that tamoxifen treatment produced a 49% reduction in the risk of invasive breast cancer in a population of women at elevated risk, the National Cancer Institute sponsored a workshop on July 7 and 8, 1998, to develop information to assist in counseling and in weighing the risks and benefits of tamoxifen. Our study was undertaken to develop tools to identify women for whom the benefits outweigh the risks. METHODS: Information was reviewed on the incidence of invasive breast cancer and of lesions, as well as on several other health outcomes, in the absence of tamoxifen treatment. Data on the effects of tamoxifen on these outcomes were also reviewed, and methods were developed to compare the risks and benefits of tamoxifen. RESULTS: The risks and benefits of tamoxifen depend on age and race, as well as on a woman's specific risk factors for breast cancer. In particular, the absolute risks from tamoxifen of endometrial cancer, stroke, pulmonary embolism, and deep vein thrombosis increase with age, and these absolute risks differ between white and black women, as does the protective effect of tamoxifen on fractures. Tables and aids are developed to describe the risks and benefits of tamoxifen and to identify classes of women for whom the benefits outweigh the risks.

    Tamoxifen risks

    Weighing the Risks and Benefits of Tamoxifen Treatment for., Risk-Benefit Profiles of Women Using Tamoxifen for Chemoprevention

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    The most commonly used medicines to lower breast cancer risk are tamoxifen and raloxifene. Other medicines called aromatase inhibitors. Tamoxifen also is used to reduce breast cancer risk in women who haven't been diagnosed but are at higher-than-average risk for the disease. Although tamoxifen has been proven to be beneficial in preventing breast cancer in high-risk women, its use has not been widely embraced.

     
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