Chloroquine mode of action

Discussion in 'Canada Pharmaceuticals Online' started by zeta, 29-Feb-2020.

  1. sercher977 Well-Known Member

    Chloroquine mode of action


    It is a rapidly acting drug, targeting the asexual stage. The mortality rate has increased along with the spread of malaria. p H of food vacuole of plasmodium specie is acidic while chloroquine is a weak base, leading to change in p H of food vacuole. More effective for long term treatment of rheumatoid arthritis as devoid of long term adverse drug reactions, especially eye changes. Use of chloroquine is declining recently due to the fact that most strains have become resistant. It rapidly enters and gets concentrated in food vacuole, present within erythrocytes. If we want to avoid relapse, Primaquine is used to eradicate tissue schizontal activity. Previously used for chemoprophylaxis, now due to development of resistance, chloroquine is not used. Anti-amoebic effect –infection caused by Entamoeba histolytica) Amebic liver abscess (as chloroquine is concentrated in the liver) because: Used for long time for rheumatoid arthritis, but because of associated ocular adverse effects, precaution is taken to have eye examination every 4 to 6 month to check retinal changes.

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    Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. General antimicrobial mechanism of action of chloroquine. Chloroquine accumulates in very high concentrations in the parasite food vacuole Geary et al. 1986. Once in the food vacuole, chloroquine is thought to inhibit the detoxification of heme. Chloroquine becomes protonated to CQ 2+ because the digestive vacuole is acidic pH 4.7 Antiprotozoal-Malaria /Mechanism of action/ may be based on ability of chloroquine to bind and alter the properties of DNA. Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte.

    Plasmodium develops, multiplies and transforms by utilizing hemoglobin of human erythrocytes. Inhibits phospholipase A2 (used rheumatoid arthritis), chemotaxis is decreased, resulting in decreased proliferation of antigen. Primarily highly effective against febrile illness, relief is quickly achieved within 24 hours. CRTF Another gene involved is chloroquine resistance transporter factor (CRTF) 4. When administered, patient becomes afebrile within 24-48 hours. Resistance has developed in Afghanistan and Khyber Pathtunkhua.

    Chloroquine mode of action

    Mechanisms of action of hydroxychloroquine and chloroquine., Antimalarial drugs Mode of action and status of resistance

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  5. Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

    • Chloroquine - FDA prescribing information, side effects and uses.
    • Chloroquine C18H26ClN3 - PubChem.
    • Aralen Chloroquine Uses, Dosage, Side Effects, Interactions, Warning.

    Chloroquine/hydroxychloroquine is extruded to the extracellular medium mostly by exocytosis and/or through the action of the multidrug resistance protein MRP-1, a cell surface drug transporter belonging to the ATP-binding cassette family, which also includes the more thoroughly studied P-glycoprotein. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Mechanism of Action Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA.

     
  6. key-kaarch XenForo Moderator

    Apparently not, according to the class-action lawsuit that has the energy drink company paying out million to consumers who bought the product based on this energy-boosting assumption. Class Action Lawsuit List Open & Current Cases Class Action Lawsuit - Amazon Sellers' Lawyer CJ Rosenbaum Things You Need To Know About Employment Class Action Lawsuits
     
  7. RidD New Member

    Access to society journal content varies across our titles. Systemic Scleroderma Skin Involvement Hyperpigmentation and. Skin Discoloration and Plaquenil - Arthritis Information Hydroxychloroquine-Induced Hyperpigmentation JCR Journal of Clinical.
     
  8. Fernandos Moderator

    Treating Lupus with Anti-Malarial Drugs Johns Hopkins. TreatmentRisksClinical significanceContraindicationsPreventionResultsBenefitsPrognosis

    Hydroxychloroquine Dosage Guide with Precautions -
     
  9. ViPppp Moderator

    Plaquenil for CFS. ProHealth Fibromyalgia, ME/CFS and Lyme Disease. I take plaquenil for Lyme. Along with two anti-biotics. I am also more tired than I was before starting treatment. And my LLMD told me to have my eyes tested every 6 months. That was the first thing he told me to do when I left his office - set up an appointment.

    Clarithromycin and hydroxychloroquine Plaquenil.