It has been found that topical application of retinoic acid (0.025%) to chronically photodamaged skin regenerated and restored elastic fibers, and that there was a significant positive correlation between the amount of newly regenerated elastic fiber and the wrinkle improvement caused by retinoic acid. Retin-A gel contains the active ingredient tretinoin 0.025%, which is a form of vitamin A used in the treatment of acne. It is not known exactly how tretinoin works, but it is thought to loosen the cells in the surface of the skin. This helps to unblock pores, so that the skin's natural oil producing glands can function normally. In addition, tretinoin increases the turnover of the skin cells, which aids the natural exfoliation of the outer layers of skin. This also helps to unblock pores and decrease the formation of blackheads (comedones) and spots. It may seem like your acne has got worse in the early weeks of treatment. 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How it works Retin-A 0.05 causes the skin to peel superficially and the cells renew faster. This leads to a reduction in spots, fine wrinkles and sun damage. Guidelines for Usage Follow the dosage instructions provided by your doctor or as mentioned in the instruction booklet/product label. Apply a thin layer of medicine in the affected area usually once a day at bedtime. You can use a cotton swab to remove any excessive medicine that may be around. Anything extra may only increase the side effects and will not improve the condition faster. Doctors recommend that you swallow the whole tablet/capsules with a glass of water unless it is specified that it can be broken or chewed. NOTE: Use only if prescribed to you and intended for your use. It may be a few weeks until you start to see the effect of treatment. Vitamin A, in any form regulates the formation of the keratin in the skin, hair and nails. 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