Tamoxifen therapy

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    Tamoxifen therapy


    For over a quarter of a century, physicians have prescribed tamoxifen to help treat patients with advanced breast cancer. In the 1990s, physicians began using tamoxifen to treat early stage breast cancer after breast surgery (lumpectomy or mastectomy). Tamoxifen has been shown to help prevent the original breast cancer from returning after breast surgery while also hindering the development of new cancers in the opposite breast. In late 1998, tamoxifen became the first drug to be approved by the U. Food and Drug Administration (FDA) to prevent breast cancer after research showed it reduced the chances of developing breast cancer by 50% in women at high risk. To grow and reproduce, breast cancer cells require the female hormone estrogen. Tamoxifen is an "anti-estrogen" and works by competing with estrogen to bind to estrogen receptors in breast cancer cells. Tamoxifen is formally known as a selective estrogen receptor modulator (SERM). No less, long-term use of tamoxifen ups the risk of getting aggressive cancer in the other breast by 440 percent. In spite of this finding, researchers insist that women should keep taking the drug because, they say, the benefits outweigh the risks. Tamoxifen has been used for over 25 years both to treat breast cancer, as well as to prevent it. Most breast cancers spread when exposed to estrogen, and since tamoxifen inhibits estrogen receptivity, it has been the standard treatment, although recently aromatase inhibitors, a new class of drugs, have taken precedence. Tamoxifen also has frequently been prescribed to high-risk women who don't have breast cancer as a prophylactic measure to stave off tumors. And, it's been used to treat osteoporosis, bipolar disorder, and prostrate cancer. But problems with tamoxifen have been surfacing for years, and now this study shows the drug causes an even more deadly version of the disease it supposedly cures. The tumors negatively associated with tamoxifen use do not feed on estrogen, no drugs on the market have been effective in treating them, and the prognosis for cancers featuring these tumors is worse than for estrogen-dependent cancers.

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    Tamoxifen Nolvadex, a hormone therapy drug, is used to treat breast cancers and to lower risk in women at high risk of breast cancer. Read about Tamoxifen. RATIONALE Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the use of estrogen by. What is Tamoxifen? Tamoxifen is a drug taken orally in pill form. For over a quarter of a century, physic

    Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Use a barrier form of birth control (such as a condom or diaphragm with spermicide) while you are using this medication and for at least 2 months after your treatment ends. Tamoxifen may also be used for purposes not listed in this medication guide. You should not use tamoxifen if you are allergic to it, or if you have a history of blood clots in your veins or your lungs, or if you are also taking a blood thinner such as warfarin (Coumadin). Before using this medicine, tell your doctor if you have liver disease, high triglycerides (a type of fat in the blood), a history of cataract, or a history of stroke or blood clot. Also tell your doctor if you if you are receiving chemotherapy or radiation treatment. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Hormone therapy using tamoxifen may fight breast cancer by blocking the use of estrogen by the tumor cells. Listing a study does not mean it has been evaluated by the U. Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. RATIONALE: Estrogen can cause the growth of breast cancer cells. It is not yet known whether giving tamoxifen alone is more effective in treating breast cancer than giving tamoxifen together with chemotherapy or after chemotherapy. PURPOSE: This randomized phase III trial is studying giving tamoxifen with or without combination chemotherapy to compare how well they work in treating postmenopausal women who have undergone surgery for breast cancer. Compare disease-free survival and overall survival of postmenopausal women with node-positive, estrogen and/or progesterone receptor-positive adenocarcinoma of the breast randomly assigned to postoperative adjuvant treatment with long-term (5 years) tamoxifen vs. Compare the relative toxicities of these three regimens. All patients are randomized on Arms I, II, and III. CAF (cyclophosphamide/doxorubicin/fluorouracil) plus concurrent and long-term tamoxifen vs. Lumpectomy patients must receive radiotherapy on Regimen A. At the discretion of the physician, mastectomy patients may receive radiotherapy on Regimen B for a tumor greater than 5 cm in diameter, 4 or more positive nodes, or extranodal extension of the tumor into the axillary fat.

    Tamoxifen therapy

    Tamoxifen - Chemotherapy Drugs - Chemocare, SWOG-8814 Tamoxifen With or Without Combination Chemotherapy in.

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  7. Tamoxifen is a hormone therapy drug used to treat ER+ breast cancer in pre- and post-menopausal women. Learn about how tamoxifen works and its side.

    • Tamoxifen Breast Cancer Care.
    • Basic Information On Tamoxifen - Imaginis.
    • Tamoxifen therapy for patients with breast cancer - The Lancet.

    В инструкции на Тамоксифен указывается, что режим дозирования устанавливается в индивидуальном порядке в зависимости от показаний и выбранной врачом схемы. For women at higher risk of breast cancer, drugs such as tamoxifen and raloxifene have been shown to help reduce the risk. Tamoxifen, sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.

     
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