Switching from immediate-release to extended-release: Use same total daily dose of metoprolol Switching between oral and IV dosage forms: Equivalent beta-blocking effect is achieved in 2.5:1 (oral-to-IV) ratio Dizziness (10%) Headache (10%) Tiredness (10%) Depression (5%) Diarrhea (5%) Pruritus (5%) Bradycardia (9%) Rash (5%) Dyspnea (1-3%) Cold extremities (1%) Constipation (1%) Dyspepsia (1%) Heart failure (1%) Hypotension (1%) Nausea (1%) Flatulence (1%) Heartburn (1%) Xerostomia (1%) Wheezing (1%) Bronchospasm (1%) Anxiety/nervousness Hallusinations Paresthesia Hepatitis Vomiting Arthralgia Male impotence Reversible alopecia Agranulocytosis Dry eyes Worsening of psoriasis Pyronie’s disease Sweating Photosensitivity Taste disturbance Lopressor and Toprol XL only Ischemic heart disease may be exacerbated after abrupt withdrawal Hypersensitivity to catecholamines has been observed during withdrawal Exacerbation of angina and, in some cases, myocardial infarction (MI) may occur after abrupt discontinuance When long-term beta blocker therapy (particularly with ischemic heart disease) is discontinued, dosage should be gradually reduced over 1-2 weeks with careful monitoring If angina worsens markedly or acute coronary insufficiency develops, beta-blocker administration should be promptly reinitiated, at least temporarily (in addition to other measures appropriate for unstable angina) Patients should be warned against interruption or discontinuance of beta-blocker therapy without physician advice Because coronary artery disease (CAD) is common and may be unrecognized, beta-blocker therapy must be discontinued slowly, even in patients treated only for hypertension Use with caution in cerebrovascular insufficiency, CHF, cardiomegaly, myasthenia gravis, hyperthyroidism or thyrotoxicosis (may mask signs or symptoms), liver disease, renal impairment, peripheral vascular disease, psoriasis (may cause exacerbation of psoriasis) May exacerbate bronchospastic disease; monitor closely Beta blockers can cause myocardial depression and may precipitate heart failure and cardiogenic shock Sudden discontinuance can exacerbate angina and lead to MI and ventricular arrhythmias in patients with CAD Worsening cardiac failure may occur during up-titration of metoprolol succinate; if such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol succinate; it may be necessary to lower the dose of metoprolol succinate or temporarily discontinue it Bradycardia, including sinus pause, heart block, and cardiac arrest, has been reported; patients with 1° atrioventricular block, sinus node dysfunction, or conduction disorders may be at increased risk Increased risk of stroke after surgery May potentiate hypoglycemia in patients with diabetes mellitus and may mask signs and symptoms Avoid starting high-dose regimen of extended-release metoprolol in patients undergoing noncardiac surgery; use in patients with cardiovascular risk factors is associated with bradycardia, hypotension, stroke, and death Long-term beta blockers should not be routinely withdrawn before major surgery; however, impaired ability of the heart to respond to reflex adrenergic stimuli may augment risks of general anesthesia and surgical procedures Metoprolol loses beta-receptor selectivity at high doses and in poor metabolizers If drug is administered for tachycardia secondary to pheochromocytoma, it should be given in combination with an alpha blocker (which should be started before metoprolol is started) While taking beta blockers, patients with history of severe anaphylactic reaction to variety of allergens may be more reactive to repeated challenge Extended release tablet should not be withdrawn routinely prior to major surgery Hydrochlorothiazide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma, which can lead to permanent vision loss if not treated; discontinue hydrochlorothiazide as rapidly as possible if symptoms occur; prompt medical or surgical treatments may need to be considered if intraocular pressure remains uncontrolled; risk factors for developing acute angle-closure glaucoma may include history of sulfonamide or penicillin allergy Caution in patients with history of psychiatric illness; may cause or exacerbate CNS depression Beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease There are no adequate and well-controlled studies in pregnant women Limited data on the use of metoprolol in pregnant women Risk to fetus/mother is unknown; because animal reproduction studies are not always predictive of human response, use if clearly needed Bioavailability: 40-50% (immediate-release) ; 65-77% (extended-release) relative to immediate release Onset: 20 min (IV), when infused over 10 min; onset may be immediate, depending on clinical setting; 1-2 hr (PO) Duration: 3-6 hr (PO); duration is dose-related; 24 hr (ER); 5-8 hr (IV) Peak plasma time: 1.5-2 hr (immediate-release); 3.3 hr (extended-release) Therapeutic range: 35-212 ng/m L The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. If you have a heart attack, your doctor may give you metoprolol tartrate (Lopressor). This drug can prevent another heart attack from occurring. However, you should be careful not to confuse it with metoprolol succinate (Toprol-XL). While the two drugs share the same first word and both treat heart-related issues, metoprolol succinate doesn’t prevent or treat a heart attack in people who’ve already had a heart attack. Learn more about the similarities and differences between these two drugs. Metoprolol tartrate and metoprolol succinate contain the same active medication: metoprolol. These salt forms, tartrate and succinate, are approved by the U. Food and Drug Administration (FDA) for different conditions. Both medications belong to a class of drugs called beta-blockers, which work by relaxing your blood vessels and slowing down your heart rate. Xanax for sleep Order silagra online Compare prices, print coupons and get savings tips for Metoprolol Generic Lopressor and other Hypertension, Heart Attack, and Angina drugs at CVS, Walgreens, and. Dispensing errors have occurred between topiramate Topamax and extended-release metoprolol Toprol-XL resulting from confused drug names. Additional. Jul 23, 2014. Metoprolol can also improve the likelihood of survival after a heart attack. Doctors prescribe the long-acting form of the drug Toprol XL to treat. I've been taking 50 mg daily (25mg morning and evening) of metoprolol since early '04. I noted an immediate decrease in resting and exercise heartrate, and a reduction in aerobic capacity. I have kept exercising and now hardly notice the difference, except when I exercise at altitude. I also initially experienced cold hands/feet, and very vivid dreams, both disappeared in time. Hello, I had been taking half inderal la 80mg for the prevention of my severe migraine attacks for 3 weeks, after the second week i had developed side effects that consisted of nightmares, problems with sleeping and a rash and itching all over my body. I had immediately visited my doctor and she put me on another beta blocker - 50mg metropolol - in hope that the side effects would dissapear. It has been a week and the itching nor the rash have not subsided. My cardiologist put me on metoprolol to reduce heartrate and I've noticed it suppresses the rash greatly ... I can even e majorly broken out and when I take my meds it reverses it ( over a few hours) which seems very significant to me because I've tried everything over this year and this is the only thing that's had any effect at all. If you are on a personal connection, like at home, you can run an anti-virus scan on your device to make sure it is not infected with malware. If you are at an office or shared network, you can ask the network administrator to run a scan across the network looking for misconfigured or infected devices. Another way to prevent getting this page in the future is to use Privacy Pass. Check out the browser extension in the Chrome Store. Metoprolol toprol Toprol XL Metoprolol Succinate Side Effects, Interactions, Warning., Toprol-XL metoprolol succinate dose, indications, adverse effects. Zithromax for pets TOPROL-XL® metoprolol succinate is approved for the treatment of high blood pressure. It can be used alone or in combination with other high blood pressure. What is TOPROL-XL® metoprolol succinate?. Metoprolol Lopressor - Side Effects, Dosage, Interactions - Drugs. Toprol XL Uses, Dosage & Side Effects -. Official Health Care Professional Web site for TOPROL-XL® metoprolol succinate extended-release tablets, a hypertension medication. My cardiologist put me on metoprolol to reduce heartrate and I've noticed it suppresses the rash greatly. I can even e majorly broken out and when I take my meds. El metoprolol es un bloqueador del receptor β 1 selectivo usado en el tratamiento de enfermedades severas del sistema cardiovascular, especialmente de la.