Why not to take tamoxifen

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  1. subzey XenForo Moderator

    Why not to take tamoxifen


    side effect of tamoxifen is blood clots, including deep vein thrombosis (DVT) and pulmonary embolus. In some cases, health care professionals may use the trade name Nolvadex when referring to the generic drug name tamoxifen. This medication is classified as an "anti-estrogen." (For more detail, see "How this drug works" section below). You should seek emergency help and notify your health care provider immediately if you develop sudden chest pain and shortness of breath. Notify your health care provider within 24 hours if you notice that one leg is swollen, red, painful and/or warm to touch and the other is not. A side effect of tamoxifen can be the development of uterine cancer. Women who have not had a hysterectomy should have regular pap smears and gyn examinations. Abnormal vaginal bleeding should be reported to your health care provider. Tamoxifen (Nolvadex) has been used for over 40 years to treat hormone-receptor positive early, locally advanced and metastatic breast cancers. Learn about tamoxifen and other hormone therapies for metastatic breast cancer. Hormone receptor-positive breast cancers need estrogen and/or progesterone (female hormones produced in the body) to grow. Tamoxifen attaches to the hormone receptor in the cancer cell, blocking estrogen from attaching to the receptor. This slows or stops the growth of the tumor by preventing the cancer cells from getting the hormones they need to grow. Tamoxifen is a pill taken every day for 5-10 years. For premenopausal women, tamoxifen may be combined with ovarian suppression. The benefits from tamoxifen last long after you stop taking it.

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    Before taking this medicine. You should not use tamoxifen if you are allergic to it. You should not use tamoxifen to reduce your risk of breast cancer if you are also taking a blood thinner such as warfarin Coumadin, Jantoven. Do not take tamoxifen if you are pregnant. It could harm the unborn baby. It does take some strength to come off of Tamoxifen as its a bit like a lifeline i.e. you feel its something you can take thats going to help but for some with the right stats and oncologists support its right for them to come off of it especially when weighed against the possible side effects. And there are a few serious possible side effects to tamoxifen that other endocrine therapies, such as aromatase inhibitors like anastrozole Arimidex, do not share. Side effects include increased risk of blood clots in the lungs and legs, stroke, and endometrial and uterine cancers.

    Tamoxifen is a hormone therapy drug taken by many premenopausal women after completing their initial treatments for estrogen receptor positive breast cancer. To treat the side effects of tamoxifen (such as hot flashes) and to help with depression, doctors often prescribe antidepressants. Yet many antidepressants can interfere, or completely cancel out, the benefits of tamoxifen. Once a woman is finished with the primary treatment of breast cancer, with therapies such as surgery, chemotherapy, and radiation therapy, she may need to take tamoxifen. For women who have estrogen receptor positive tumors, hormone therapy can reduce the risk of the cancer coming back (recurrence) by around 50 percent. The choice of medication depends on menopausal status. If a woman is premenopausal, tamoxifen is usually the drug of choice. (For those who are postmenopausal, or who are premenopausal but have received ovarian suppression therapy, an aromatase inhibitor is usually used instead). Tamoxifen (Nolvadex®) is a medication in pill form that has been used for more than 25 years to treat breast cancer in women and men. Tamoxifen is one of the most common endocrine therapy drugs. It has been shown to decrease the chance of recurrence in some early-stage breast cancers and to prevent the development of cancer in the opposite breast. Tamoxifen can also slow or stop the growth of cancer cells present in the body. There are an estimated 29 million women at increased risk for breast cancer in this country, and tamoxifen may offer another alternative to watchful waiting or prophylactic (preventative) mastectomy. Tamoxifen is classified as a selective estrogen receptor modulator (SERM) and works as an anti-estrogen: While the hormone estrogen promotes the growth of breast cancer cells, tamoxifen works by blocking estrogen from attaching to estrogen receptors on these cells. By blocking the estrogen receptors, it is believed that the growth of the breast cancer cells will be halted.

    Why not to take tamoxifen

    Antidepressants That Interact With Tamoxifen - Verywell Health, Why I have decided not to take the Tamoxifen - Breast cancer.

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  5. Tamoxifen has a wide range of systemic effects, possibly acting on every estrogen. 2 to 4 times higher than for postmenopausal women not taking tamoxifen.

    • Tamoxifen in postmenopausal women a safety perspective. - NCBI.
    • Do I Have To Take Tamoxifen – Women’s Health Network.
    • Tamoxifen Drug Interactions and Genetics - Verywell Health.

    Aug 31, 2017. More and more women are choosing not to take them, but is this a. Aromatase inhibitors have similar side effects to those of Tamoxifen but. Nov 5, 2008. Experts already know that taking tamoxifen for five years increases survival. It's not disastrous if women simply forget to take the occasional. You've gotten great replies about how to do your personal risk vs. benefit analysis, but I'll tell you why I chose NOT to take Tamoxifen, even though I'm "high risk" huge total area of DCIS, including a 4.5cm palpable tumor, etc. and my DCIS is over 90% ER+.

     
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