Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Does plaquenil have small amounts of malaria in it Chloroquine colon cancer Although rare, Plaquenil can cause significant toxicity to the eye with prolonged use. Also, Plaquenil may have various systemic side effects that are not related to the eyes. These too are rare and include nerve weakness, hallucinations, psoriasis and changes in hair color. Plaquenil What You Need to Know. This drug does not have a strong effect on the immune system, so vaccines recommended by other physicians are generally. Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How does plaquenil affect the eyes Protecting your eyesight when taking Plaquenil Lupus., Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Corneal pics chloroquine side effects SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Taking Plaquenil for Rheumatoid Arthritis. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Yellow eyes or skin; Symptoms of overdose. Drowsiness; dry mouth; increased thirst; loss of appetite; mood changes; no pulse or blood pressure; numbness or tingling in the hands, feet, or lips; unconsciousness; Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Abnormal Function Of The Cornea In The Eye Corneal Opacity, A Scarring Disorder That Results In Clouding Of The Cornea Of The Eye If experienced, these tend to have a Less Severe expression Patients using plaquenil may experience important but rare side effects that affect the eyes, including damage to the retina back of the eye, cornea front of the eye, and eyelids. These side effects typically occur on high doses of the medication and increase with duration of use.