The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Hydroxychloroquine dose sle Chloroquine tablets side effects Aralen phosphate cost Methotrexate is once a week usually and most of the side effects would hit the next day so some people choose to take it on a Friday or Saturday night and sleep through any potential side effects some people report that caffeine may lower the efficacy of methotrexate, though results have been inconclusive. After an inadequate response to methotrexate, several treatments were statistically superior to oral methotrexate for ACR50 response triple therapy, methotrexate plus hydroxychloroquine, methotrexate plus leflunomide, methotrexate plus intramuscular gold, methotrexate plus most biologics, and methotrexate plus tofacitinib. Compare Chloroquine vs Hydroxychloroquine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Chloroquine rated 10.0/10 vs Hydroxychloroquine rated 6.7/10 in overall patient satisfaction. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Difference between hydroxychloroquine and methotrexate Is Injectable Methotrexate or Oral Methotrexate Better?, Methotrexate monotherapy and methotrexate combination therapy with. Chloroquine injectionHydroxychloroquine price canadaPlaquenil and liver problems Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. Effects of methotrexate and hydroxychloroquine combination.. Chloroquine vs Hydroxychloroquine Comparison -. Combinations of conventional & biologic DMARDs. Dec 15, 2010 hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. For RA patients, methotrexate is used in a completely different way.” At these extremely lower doses, methotrexate has a completely different effect on the body. It is a disease-modifying agent that reduces inflammation. “I like to say it’s the difference between swimming in a pool and drinking a glass of water. In a word, yes. Not actual vomiting, but distinct nausea and muzzyness. Worst of all depression. As the addition of Hydroxychloroquine to my cocktail methotrexate and Enbrel Anti-TNF, didn't seem to be making any difference, I stopped it a few weeks ago.